International Journal of Drug Delivery Technology · Oct 22, 2026
CARDIAC AGING AND MITOCHONDRIAL DYSFUNCTION: IMPLICATIONS FOR CARDIOVASCULAR DISEASE
Cardiac aging is a major risk factor for cardiovascular diseases (CVD), and understanding its underlying mechanisms is crucial for developing effective anti-aging treatments.This review paper provides a comprehensive overview of the molecular processes underlying cardiac aging, with a focus on mitochondrial dysfunction and its role in CVD.We examine the contributions of various pre-clinical models, including dog, fruit fly, and mice, to our understanding of cardiac aging processes.The review also explores the intricate interplay between mitochondrial dysfunction, oxidative stress, and age-related changes in cardiovascular tissues.We discuss the potential of mitochondrial DNA copy number, energy generation, calcium regulation, and DNA methylation as diagnostic and therapeutic targets in metabolic and cardiovascular disorders.The review also highlights the complex relationship between mitochondrial dysfunction and CVD, including the role of oxidative stress, DNA mutations, and impaired oxidative phosphorylation.Ultimately, this review aims to provide a comprehensive understanding of the molecular processes underlying cardiac aging and the pivotal role of mitochondrial dysfunction in the pathogenesis of CVD.