Preprint · Sep 21, 2020

Investigation of the possible correlation between Idiopathic Parkinson’s disease and Diabetes mellitus in Egyptian elderly patients (A pilot study)

By Elgnainy A

Objectives: To study the diabetes-Parkinson’s disease (PD) linkage. Methods: The investigators recorded the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) score for 60 diabetic patients, 30 patients were treated with metformin-inclusive sulfonylurea, 30 patients were treated with sulphonylurea monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75-g Oral Glucose Tolerance Test for (22) non-diabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the unified Parkinson’s disease rating scale (UPDRS). Results: Diabetics recorded higher scores of RBDSQ than controls (P<0.001), no differences related to the antidiabetic therapy. In non-diabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p <0.001) and T1.5 (p = 0.047) than controls. Moreover, the total area under time curve for the blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs 245.65 ± 48.63 mg.hr. / dL; p = 0.013). Higher blood glucose levels were associated with motor abnormalities, Diabetic PD patients recorded higher scores of UPDRS (p <0.001). Conclusion: Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them probably increasing the risk of the other.

doi.org/10.22541/au.160071248.87480469Open accessPopulations