Research Square · Feb 5, 2021
Relationship Between Sleep Duration and Stroke in Middle-Aged and Elderly in Guiyang: A Cross-Sectional Survey
By Liu L, Yang J, Wang J et al.
Abstract Background: With over 2 million new cases annually, stroke is associated with the highest disability-adjusted life-years lost of any disease in China. The relationship between sleep time and stroke has not been concluded yet. To study the relationship between sleep duration and stroke in middle-aged and elderly in Guiyang, China. Methods: This study was a cross-sectional survey carried out in 40-99-years-old permanent residents in Guiyang. Yunyan, Wudang, and Baiyun districts and Xiuwen County were selected by stratified multilevel sampling for a face-to-face survey. Demographics, stroke, sleep behavior, and health behavior were collected. Multivariable logistic regression models were used to gradually adjust the association between sleep duration and stroke for possible confounding factors. Results: A total of 5065 participants were included, and 126 (2.5%) had a stroke. Insufficient sleep (<7 h) was observed in 11.0%, sufficient sleep (7-9 h) in 69.4%, and long sleep (>9 h) in 19.6%. Sleep duration and stroke prevalence showed a U-shaped distribution. When taking the sleep duration of 7-9 h as reference, sleep duration >9 h was associated with stroke (all P<0.05) in the univariable model (OR=2.68, 95%CI: 1.83-3.93) and in the multivariable models 1 (OR=2.35, 95%CI: 1.59-3.47), 2 (OR=2.27, 95%CI: 1.53-3.37), 3 (OR=2.25, 95%CI: 1.51-3.33), and 4 (OR=2.11, 95%CI: 1.39-3.19). There were no significant differences between the <7 and 7-9 h groups (P>0.05). Conclusion: Long sleep duration (>9 h) is independently associated with stroke in middle-aged and elderly people in Guiyang.