Complex Issues of Cardiovascular Diseases · Mar 18, 2026

CHANGES IN INDICATORS OF FRAILTY IN PATIENTS AFTER DIRECT MYOCARDIAL REVASCULARIZATION

By Евгеньевна КК, Дмитриевич БЕ, Барбараш ОЛ

Highlights In the era of rapid population aging, frailty has become one of the most significant public health concerns because of the increased risk of adverse outcomes, such as functional decline, greater medical resource utilization, and higher mortality rates. In low- and middle-income countries, there is a growing need to identify and monitor the dynamics of frailty in order to develop measures to maintain a high quality of life for ageing populations. Aim. To study the changes in indicators of pre-frailty and frailty syndrome in patients within three years after primary elective coronary artery bypass grafting. Methods . The study included 387 patients with multivessel coronary artery disease before undergoing direct myocardial revascularization. Various diagnostic approaches were used to identify pre-frailty and frailty syndrome, such as a multi-stage diagnostic algorithm from the frailty recommendations of the Russian Public Organization «Russian Association of Gerontologists and Geriatricians» (2020), the «PRISMA-7» questionnaire, the criteria for the Fried frailty phenotype, and the 5-factor modified frailty index (mFI-5). Statistical processing of the results was carried out using the IBM SPSS Statistics 26.0.0 software. Results. The results of the analysis of the clinical and anamnestic characteristics of the sample revealed a classic portrait of patients with multivessel coronary artery disease, the majority of patients were men (73.1%), the median age was 65 [59; 69] years. The incidence of pre-frailty among patients with coronary artery disease ranged from 15.0 to 42.4%, and the incidence of frailty syndrome ranged from 22.5 to 71.6%. Within three years after elective coronary bypass surgery, according to several diagnostic approaches, the manifestations of pathological aging of the body can increase by an average of 5.0–10.0%, whereas using European «PRISMA-7» questionnaire revealed significant differences (p = 0.045). Conclusions . The progression of frailty in patients with coronary artery disease three years after direct myocardial revascularization varies on average from 5.0 to 10.0% according to the results of the study.

doi.org/10.17802/2306-1278-2025-14-6s-31-39 Open access Biomarkers