Scientific Reports · Nov 3, 2026
Analysis of mental disorders and associated factors in high-risk population of colorectal tumors: a cross-sectional study
By Shen Y, Li Z, Yu M et al.
This study focused on high-risk individuals with colorectal tumors, aiming to explore the relationship between psychological factors and colorectal tumors. Additionally, it further analyzed the factors associated with the presence of colorectal tumors. This study included 562 participants, comprising 278 in the low-risk group and 284 in the high-risk group. Participants’ psychiatric symptoms were assessed using HAMD-17, HAMA, and PSQI scales. Based on endoscopic and pathological results, participants were stratified into tumor/non-tumor groups, and advanced adenoma, colorectal cancer, advanced neoplasia subgroups were analyzed. Age-based 1:1 propensity score matching (PSM) was performed to eliminate confounding. Statistical analyses were performed using SPSS 24.0 software. After PSM, the high-risk group had significantly higher total HAMD scores and total HAMA scores than the low-risk group ( P < 0.05). The high-risk group also exhibited significantly higher total PSQI scores, sleep quality, sleep efficiency, and daytime functioning scores ( P < 0.05). Binary Logistic regression analysis revealed that age (OR = 1.061, 95%CI:1.038–1.083, P < 0.001) and total PSQI score (OR = 1.512, 95%CI:1.003–2.279, P = 0.048) were associated with the presence of colorectal tumors in the high-risk group. This cross-sectional study found that individuals at high risk for colorectal tumors have higher rates of emotional problems and sleep disturbances. Individuals at high risk for colorectal tumors have higher rates of emotional problems and sleep disturbances. Age and sleep quality are independently associated with the colorectal tumors in the high-risk population.