Unveiling the Temporal Dynamics of White Matter Hyperintensities Related to Alzheimer’s Disease in Down Syndrome

Abstract

Background: Down syndrome (DS) is a genetically determined form of Alzheimer’s disease (AD) characterized by a low prevalence of traditional age‐related vascular risk factors. Emerging evidence indicates that white matter hyperintensities (WMH) are frequent in DS and linked to small vessel disease and neurodegeneration.