Harmonization Remains Unresolved: The Case of White Matter Hyperintensity Using ComBat And Deming Regression

Abstract

Background: Multi‐site aging and dementia studies are challenged by data heterogeneity caused by scanner (manufacturer and protocol) related variability. Quantitative analysis of white matter hyperintensity (WMH) from pooled samples, a traditional marker of cerebrovascular disease, is sensitive to machine variability.

The paper