Rest Interrupted: Plasma GFAP, Cerebral Microbleeds, and Sleep Disturbances in Neurodegeneration – Insights from the Southeast Asian BIOCIS Study

Abstract

Background: Rest is the cornerstone of mental clarity. Chronic sleep disturbances disrupt these processes, driving neuroinflammation, astrocytic dysfunction and neurodegeneration. Glial fibrillary acidic protein (GFAP), a marker of astrocytic activation, has been linked to sleep‐wake disruptions in Alzheimer's disease (AD).