Longitudinal associations of intra‐individual cognitive variability with dementia, cognitive change and PET amyloid‐ß in adults with Down syndrome: data from the Alzheimer's Biomarker Consortium‐ Down Syndrome (ABC‐DS)

Abstract

Background: Because of the high incidence of Alzheimer's disease (AD) amyloid‐b pathology in individuals with Down syndrome (DS), they are considered an ideal target population for anti‐amyloid therapy trials. However, not all individuals with DS develop dementia.