The Impact of Early Life Bilateral Salpingo‐Oophorectomy on the Nucleus Basalis of Meynert

AAIC 2025 Abstract

Abstract

Background: Alzheimer's disease (AD) disproportionately affects women. Women with early‐life bilateral salpingo‐oophorectomy (BSO) have a yet higher risk of late‐life AD. The cholinergic pathway in the basal forebrain, comprising cholinergic nuclei 1, 2, and 3 (Ch123) and the nucleus basalis of Meynert (NBM, i.e.

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