Genetic and Metabolic Markers for Cognition: The Interplay of Hyperhomocysteinemia and ApoE Genotype

Abstract

Background: The presence of ApoE4 allele is known to be the most important genetic risk factor for Late Onset Alzheimer's Disease (LOAD). Hyperhomocysteinemia (HHcy), a cardiovascular risk factor, is also being extensively studied for its role in increasing the risk of cognitive decline in the elderly.