Improving VCID Risk Stratification: A NfL and PSMD Multi‐Biomarker Approach

Abstract

Background: Neurofilament Light (NfL) is a broad biomarker of neuroaxonal injury elevated in neurological diseases, including cerebral small vessel disease (cSVD). However, NfL's non‐specificity limits its effectiveness in assessing susceptibility/risk for Vascular Contributions to Cognitive Impairment and Dementia (VCID).