White Matter Hyperintensities burden is associated with higher plasma NfL and poorer global cognition in MCI: Findings from the Southeast Asian BIOCIS study

Abstract

Background: NfL, a critical neuronal cytoskeleton structural protein has been demonstrated to be increased with the presence of White Matter Hyperintensities (WMH). Nevertheless, the effect of NfL expression in the context of WMH burden and cognition in younger versus older cognitively impaired adults, has yet to be completely elucidated.