AAIC 2025 Abstract
The Impact of Striatal Dopaminergic Deficits and Alpha‐Synucleinopathy on Cognitive Function in REM Sleep Behavior Disorder
Study in peopleMechanisms
Abstract
Background: Presynaptic protein α‐synuclein (αSyn) plays a role in Alzheimer's disease (AD) and Parkinson's disease (PD) with evidence suggesting αSyn pathology preceding and driving striatal dopaminergic neurodegeneration in PD.


