Staging and Pseudotime Inference of Alzheimer's Disease Progression

Abstract

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by amyloid‐beta plaques (A), neurofibrillary tangles (T), and neuronal loss (N), commonly abbreviated A/T/N. Understanding the spatial progression of neurodegeneration is key to predicting disease trajectories and outcomes.

The paper