Sex‐specific patterns of a machine learning‐derived Alzheimer's brain atrophy imaging signature in participants without diagnosed cognitive impairment: A multi‐cohort study

Abstract

Background: We investigated sex differences in a machine learning‐derived imaging signature of AD brain atrophy (i.e., SPARE‐AD ⁵ ), in relation to age, genetic factors ( APOE ε4 allele), and multi‐organ biological age gap (BAG 2,3 ).