Amyloid quantification in the oldest‐old: selecting regions for optimizing correspondence between pathology at autopsy and amyloid PET

Abstract

Background: Positron emission tomography (PET) is the current gold standard for assessing amyloid burden in vivo and is often quantified using standardized uptake value ratios (SUVR). However, there are multiple ways to compute SUVRs, including using different regions of interest (ROI) or different reference regions.