Anatomical characterization of pTau217 in sporadic AD: Revealing seeding and neurodegeneration within higher‐order cortical circuits

Abstract

Background: Developments in Alzheimer's disease (AD) have revealed a novel fluid‐based pT217‐tau biomarker, in CSF and plasma, that predicts AD prior to cognitive deficits. Understanding the role of pT217‐tau is important in assessing efficacy of novel treatments aimed at early‐stage disease.