P2RX7 deficiency prevents tau‐mediated neurodegeneration via regulation of microglial response and suppression of extracellular vesicles containing tau and toxic mitochondrial content

Abstract

Background: We previously identified a novel mechanism describing how pathological tau transfers via extracellular vesicles (EVs) in Alzheimer's disease (AD). Targeting EV secretion to mitigate tau transfer is, therefore, a promising therapeutic approach for AD.

The paper