MechanismsHumans
X‐linked gene expression is associated with plasma p ‐tau217 levels via Aβ‐PET and sex in cognitively unimpaired older adults
AAIC 2025 Abstract
Abstract
Background: Higher levels of plasma p ‐tau ₂₁₇ are closely associated with increased Aβ‐PET burden, and subsequent cognitive decline in older adults, supporting it as a sensitive, early marker of AD.
The paper
Mabel Seto, Hannah M Klinger, Vaibhav A. Janve, Rachel F. Buckley
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Jane A. Brown, Colin J. Birkenbihl, Gillian Coughlan, Diana L Townsend, Ting‐Chen Wang, Michael J Properzi, Michelle J. Clifton, Bernard Jimmy Hanseeuw, Jasmeer P. Chhatwal, Hyun‐Sik Yang, Robert A. Rissman, Paul S. Aisen, Madison Cuppels, Michael Donohue, Rema Raman, Keith A. Johnson, Reisa Anne Sperling, Logan C. Dumitrescu, Timothy J. Hohman,Harvard University
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
