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AAIC 2025 Abstract

APOE4 carriers across neurodegenerative diseases have common systemic biological dysfunction

By Artur Shvetcov, Erik C. B. Johnson, Laura M. Winchester, Show 5 more authorsCaitlin A. Finney
Study in peopleMechanisms
Paper

Abstract

Background: Apolipoprotein E ε4 (APOE4) is the biggest genetic risk factor for sporadic Alzheimer's disease (AD). There is also evidence that APOE4 carriers have an increased risk of and/or altered disease progression for other age‐associated neurodegenerative diseases, including frontotemporal dementia (FTD) and Parkinson's disease (PD).

The paper

Artur Shvetcov, Erik C. B. Johnson, Laura M. Winchester, Show 5 more authorsCaitlin A. Finney

UNSW Sydney; The University of Sydney

AAIC 2025 Abstract, 23 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70855_099496

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