An observational analysis of 10,977 survey participants linked intake of a major tea compound to lower biological age acceleration and lower mortality.An observational analysis of 10,977 survey participants linked intake of a major tea compound to lower biological age acceleration and lower mortality.
Silencing a neuron subgroup in young mice impaired how brain cells responded to location; older mice had fewer cells in this subgroup.Silencing a neuron subgroup in young mice impaired how brain cells responded to location; older mice had fewer cells in this subgroup. Old mice had a smaller share of grid cells, neurons that help map locations, and less stable…
Laboratory experiments found that restoring one fatty acid caused senescent cells to die through an iron-dependent process called ferroptosis.Laboratory experiments found that restoring one fatty acid caused senescent cells to die through an iron-dependent process called ferroptosis.
Paired measurements in 99 people showed greater variation in microbial than metabolic profiles, suggesting the body may initially buffer microbial changes.Paired measurements in 99 people showed greater variation in microbial than metabolic profiles, suggesting the body may initially buffer microbial changes.
Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training. In 32 male rats aged 9, 18, 21 and 25 months, researchers combined kidney imaging with measurements…
Protein changes appeared by age 30 in immature human eggs, compared with age 35 or 40 in mature eggs. Mature eggs showed changes later, at 35 or 40.Protein changes appeared by age 30 in immature human eggs, compared with age 35 or 40 in mature eggs. Mature eggs showed changes later, at 35 or 40.
A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.A 12-week randomized trial of 69 adults aged 60–85 found differences between groups in breathing-muscle strength and selected biological markers, but not lung function.
Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing…Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing structures.
Smartphone assessments of 318 adults aged 70–90 across up to six annual rounds found limited links between loneliness and later cognitive change.Smartphone assessments of 318 adults aged 70–90 across up to six annual rounds found limited links between loneliness and later cognitive change.
Experiments in stem cells found that increasing a protein preserved the structure of their DNA-containing nuclei and counteracted senescence, a state in which cells stop…Experiments in stem cells found that increasing a protein preserved the structure of their DNA-containing nuclei and counteracted senescence, a state in which cells stop dividing.
Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.
Median worst-group gaps in distinguishing outcomes were 0.028 by age, versus 0.004 by sex and 0.016 by race.Median worst-group gaps in distinguishing outcomes were 0.028 by age, versus 0.004 by sex and 0.016 by race. Researchers computationally tested four artificial intelligence models using 5.4 million electrocardiograms—recordings of…
Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.
Who was studiedPeople across multiple geographic regions
What changedPersonalized lifespan trajectories modeled from retinal photographs were associated with observed mortality outcomes, including age of death
The catchHealth improvements and survival gains from using the model for screening were not measured
Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.
Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.
In a 28-day randomized trial of 48 young and older women, creatine was associated with improvements on several cognitive tests compared with placebo.In a 28-day randomized trial of 48 young and older women, creatine was associated with improvements on several cognitive tests compared with placebo. They received 3 grams daily or placebo for 28 days.
Stopping statins was linked to a hospitalization risk 37.6 per 1,000 patients higher at one year than continuing them.Stopping statins was linked to a hospitalization risk 37.6 per 1,000 patients higher at one year than continuing them. In an English retrospective observational cohort study, researchers compared 65,727 persistent users of…
The workflow increased protein coverage 3–6-fold and identified 3,992 groups of proteins from 20 microliters of mouse serum.The workflow increased protein coverage 3–6-fold and identified 3,992 groups of proteins from 20 microliters of mouse serum. In a cross-sectional analysis, researchers examined serum—the liquid left after blood clots—from 30 mice…
Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.
An experiment tested navitoclax in mice with diet-induced liver disease; the packaged drug also reduced a disease activity score and scarring-related profiles.An experiment tested navitoclax in mice with diet-induced liver disease; the packaged drug also reduced a disease activity score and scarring-related profiles.
A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.A cell experiment using mouse colon organoids linked gains in certain DNA marks to biological aging rather than activation of a cancer-linked mutation.
The model’s ability to distinguish people with and without arterial stiffness scored 0.780 in internal validation and 0.772 in checks at independent hospitals.The model’s ability to distinguish people with and without arterial stiffness scored 0.780 in internal validation and 0.772 in checks at independent hospitals.
Who was studied36,412 adults with diabetes, against models using classical risk factors alone
What changedThe eye-image model distinguished people with and without arterial stiffness better than risk-factor-only models, scoring 0.772 in external validation
The catchScreening's effects on health outcomes were not measured
The high-risk group included 20% of women and 9% of men in a Swedish survey that followed 6,328 people for 42 years.The high-risk group included 20% of women and 9% of men in a Swedish survey that followed 6,328 people for 42 years. An observational study followed 6,328 people in a population-representative Swedish survey over 42 years and…
An observational study in patients with lymphoma linked expanding blood-cell clones to poorer immune recovery and treatment-related blood cancers after engineered…An observational study in patients with lymphoma linked expanding blood-cell clones to poorer immune recovery and treatment-related blood cancers after engineered immune-cell therapy.
At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.At the next assessment, estimated deterioration risk was 54.5% after recent recovery versus 34.9% with consistently favorable assessments in one of three cohorts.
The observational research platform combines 10 cohorts with 2,181,318 adults and has documented 139,843 deaths through national records.The observational research platform combines 10 cohorts with 2,181,318 adults and has documented 139,843 deaths through national records. In China, 2,181,318 adults aged 18 or older enrolled between 2008 and 2024 in the 10 cohorts…
Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.
Eleven-year survival was 21.0% with type 2 diabetes, cardiovascular disease and chronic kidney disease, versus 54.2% with type 2 diabetes alone.Eleven-year survival was 21.0% with type 2 diabetes, cardiovascular disease and chronic kidney disease, versus 54.2% with type 2 diabetes alone.
In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination.In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination. Researchers analyzed long-term pesticide safety experiments in rodents, with at least 50 animals per dose…
Patients with physical frailty worsened 1.52 points per year faster on a dementia severity scale than those without frailty while receiving lecanemab.Patients with physical frailty worsened 1.52 points per year faster on a dementia severity scale than those without frailty while receiving lecanemab.
