The analysis identified 22 links between immune cell gene activity and aging measures, with strong evidence of a shared genetic signal for 14.The analysis identified 22 links between immune cell gene activity and aging measures, with strong evidence of a shared genetic signal for 14.
Older mice given vanadyl sulfate in drinking water for 13 weeks had better hanging endurance and less fat accumulation than controls.Older mice given vanadyl sulfate in drinking water for 13 weeks had better hanging endurance and less fat accumulation than controls. Male mice given oral vanadyl sulfate, a mineral dietary supplement, lived longer in animal…
In mouse experiments, blocking serotonin, a brain signaling chemical, from acting in one brain region restored youthful activity levels and strength.In mouse experiments, blocking serotonin, a brain signaling chemical, from acting in one brain region restored youthful activity levels and strength.
Worms deprived of food for 24 hours retained their survival benefit when food odor increased reproduction, challenging an explanation based on saving resources.Worms deprived of food for 24 hours retained their survival benefit when food odor increased reproduction, challenging an explanation based on saving resources.
Aged mouse bone marrow stem cells treated for 48 hours in lab experiments broke down more fatty acids and regained the ability to develop into bone-forming cells.Aged mouse bone marrow stem cells treated for 48 hours in lab experiments broke down more fatty acids and regained the ability to develop into bone-forming cells.
New and persistent leakage were linked to 2.28 and 2.16 times the odds of worsening daily functioning, respectively, versus no leakage at either assessment.New and persistent leakage were linked to 2.28 and 2.16 times the odds of worsening daily functioning, respectively, versus no leakage at either assessment.
Chair-rise performance improved versus waitlist controls after 12 weeks, with a standardized effect size of 0.54 measuring the difference between groups.Chair-rise performance improved versus waitlist controls after 12 weeks, with a standardized effect size of 0.54 measuring the difference between groups.
An experiment in genetically altered mice found that limiting the buildup of chemically altered fats helped maintain blood stem-cell properties and immune-cell…An experiment in genetically altered mice found that limiting the buildup of chemically altered fats helped maintain blood stem-cell properties and immune-cell development.
In an observational study of 3,328 adults, a model using joint movements predicted 1,887 of 3,210 tested health measures.In an observational study of 3,328 adults, a model using joint movements predicted 1,887 of 3,210 tested health measures. The movements of 3,328 adults were recorded with a single depth-sensing camera during five motor tasks in an…
Each 5°F increase in long-term average daily maximum temperature was linked to a 5% higher relative risk of death among California cohort participants.Each 5°F increase in long-term average daily maximum temperature was linked to a 5% higher relative risk of death among California cohort participants.
Comparisons of young and aged mice identified blood-forming precursor cells that retained their long-term ability to replenish lymphocytes, a type of immune cell.Comparisons of young and aged mice identified blood-forming precursor cells that retained their long-term ability to replenish lymphocytes, a type of immune cell. Precursor cells can develop into more specialized blood cells.
In goat egg-cell experiments, a supplement restored a metabolic molecule, improved measures of cell function and improved early embryo development.In goat egg-cell experiments, a supplement restored a metabolic molecule, improved measures of cell function and improved early embryo development.
In 27-month-old mice, sustained growth signaling increased inflammatory gene activity, which five months of dietary rapamycin did not suppress.In 27-month-old mice, sustained growth signaling increased inflammatory gene activity, which five months of dietary rapamycin did not suppress.
An observational study linked maternal income at birth more strongly than later income to DNA-based aging measures in children at ages 9 and 15.An observational study linked maternal income at birth more strongly than later income to DNA-based aging measures in children at ages 9 and 15.
Compared with the general population, dementia was linked to 5.01 years lost in men with longer education and 5.29 in women, versus 3.99 for both with shorter education.Compared with the general population, dementia was linked to 5.01 years lost in men with longer education and 5.29 in women, versus 3.99 for both with shorter education.
In mouse experiments, prolonged exposure to a gut microbial bile acid contributed to blood stem cell loss, while a high-fiber diet reduced age-associated decline.In mouse experiments, prolonged exposure to a gut microbial bile acid contributed to blood stem cell loss, while a high-fiber diet reduced age-associated decline.
Laboratory experiments in mice aged 12–14 months and 3–4 months identified a protein that helped move calcium-entry channels to the surface of older mice’s artery cells.Laboratory experiments in mice aged 12–14 months and 3–4 months identified a protein that helped move calcium-entry channels to the surface of older mice’s artery cells.
Persistent underweight was linked to higher mortality than remaining normal weight, with a hazard ratio of 1.61, a measure comparing death rates.Persistent underweight was linked to higher mortality than remaining normal weight, with a hazard ratio of 1.61, a measure comparing death rates.
Experiments in lab-grown ovarian cells found that packages from dying immune cells disrupted energy production; inhibiting a small RNA molecule eased the effects.Experiments in lab-grown ovarian cells found that packages from dying immune cells disrupted energy production; inhibiting a small RNA molecule eased the effects.
Peak oxygen use increased by 2.80 milliliters per kilogram per minute more with soccer than with usual care over 14 weeks.Peak oxygen use increased by 2.80 milliliters per kilogram per minute more with soccer than with usual care over 14 weeks. Adults aged 40–70 with type 2 diabetes took part in a randomized trial involving 111 people.
An experiment comparing 8- and 56-week-old female mice found the worst damage after interrupted liver blood flow in older mice missing a DNA-sensing enzyme.An experiment comparing 8- and 56-week-old female mice found the worst damage after interrupted liver blood flow in older mice missing a DNA-sensing enzyme.
Among adults aged 75 and older, major walking limitations were projected to affect 35% by 2040, compared with 27% in 2024.Among adults aged 75 and older, major walking limitations were projected to affect 35% by 2040, compared with 27% in 2024. Finnish adults aged 55 and older were the focus of an observational analysis of seven cross-sectional…
A model projected 6.21 million older EU adults with both cardiovascular disease and severe dependency in 2050, up from 4.06 million in 2021.A model projected 6.21 million older EU adults with both cardiovascular disease and severe dependency in 2050, up from 4.06 million in 2021.
An analysis of 24 rhesus macaques identified 594 age-associated changes in levels of RNA versions, some shared between sexes and others sex-specific.An analysis of 24 rhesus macaques identified 594 age-associated changes in levels of RNA versions, some shared between sexes and others sex-specific.
Against placebo, empagliflozin’s hazard ratios—relative event rates over time—were 0.91, 0.64 and 0.49 for zero, one or multiple documented heart scan criteria.Against placebo, empagliflozin’s hazard ratios—relative event rates over time—were 0.91, 0.64 and 0.49 for zero, one or multiple documented heart scan criteria.
Who was studied5,988 patients with heart failure with preserved ejection fraction
What changedEmpagliflozin lowered heart failure hospitalization or cardiovascular death most with multiple scan abnormalities: hazard ratio 0.49 versus placebo
The catchScan reliability and methods were uncontrolled, and scans could capture acute or stable heart failure
Mutation carriers had a higher relative rate of death than noncarriers, with an adjusted hazard ratio of 1.26.Mutation carriers had a higher relative rate of death than noncarriers, with an adjusted hazard ratio of 1.26. UK Biobank participants hospitalized with heart rhythm disorders—53,149 people with a median age of 69—were studied in…
Death risk was 21% higher for an increase in heatwave days spanning the middle half of exposure levels, over a median 12.8 years.Death risk was 21% higher for an increase in heatwave days spanning the middle half of exposure levels, over a median 12.8 years. Among 332,175 UK Biobank adults enrolled between 2006 and 2010, a prospective cohort study tracked…
Sorting individual mitochondria in mouse egg cells revealed age-related DNA differences that pooled measurements missed, with supplementation producing different effects…Sorting individual mitochondria in mouse egg cells revealed age-related DNA differences that pooled measurements missed, with supplementation producing different effects across groups.
Over 12 months, the adjusted risk ratio for death was 0.61 for metformin prescriptions versus prescriptions for another diabetes drug.Over 12 months, the adjusted risk ratio for death was 0.61 for metformin prescriptions versus prescriptions for another diabetes drug. Among 53,332 adults aged 30–85 with type 2 diabetes and COVID-19, a retrospective observational…
Cell experiments found that these immune cells also promoted resistance to chemotherapy by changing tumor cell behavior.Cell experiments found that these immune cells also promoted resistance to chemotherapy by changing tumor cell behavior. The researchers also analyzed gene activity in individual cells and identified abundant senescent T cells in…
Scores on a test of overall thinking rose about 2.2 points with the 12-week program versus 0.2 points with standard care alone.Scores on a test of overall thinking rose about 2.2 points with the 12-week program versus 0.2 points with standard care alone. Sixty adults aged 65–83 with high blood pressure and mild to moderate cognitive impairment took part…
Among 6,351 adults aged 40 and older, the link between higher blood selenium and lower frailty leveled off above about 180–190 micrograms per liter.Among 6,351 adults aged 40 and older, the link between higher blood selenium and lower frailty leveled off above about 180–190 micrograms per liter.
Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice. Primary human hematopoietic stem cells, which give rise to blood cells, received RNA-delivered tools for…
Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.
The highest versus lowest third of a cumulative combined score had higher relative risk of multiple diseases, with a hazard ratio of 6.52.The highest versus lowest third of a cumulative combined score had higher relative risk of multiple diseases, with a hazard ratio of 6.52. The 5,171 middle-aged and older Chinese women and men in a prospective observational cohort…
Who was studied5,171 middle-aged and older Chinese adults
What changedMultiple chronic diseases were more likely with highest versus lowest cumulative combined frailty and insulin-resistance scores (hazard ratio 6.52)
The catchParticipant-reported disease diagnoses could misclassify who developed multiple chronic diseases
